Drug hypersensitivity reaction (DHR) is defined as an immunologically mediated\nresponse to a pharmacology agent. Some reactions require prior sensitization\nand some do not. The interactions between different drugs and the\nimmune system occur by different mechanisms leading to variable clinical\nfeatures. Some reactions are simple and do not alter patient quality of life.\nSome are life threatening and require immediate recognition and appropriate\ntherapy. Confirming the diagnosis of DHR is often challenging. The environment\nin the Intensive care units (ICU) is considered high risk place for DHR\ndevelopment as it offers most of the risk factors. In this review, we offer a delicate\ncombined approach that allows an accurate diagnosis of most of the\nDHRs encountered in the ICU.
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